209959-80-8Relevant academic research and scientific papers
NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
-
Page/Page column 76, (2009/10/01)
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors
Quan, Mimi L.,Ellis, Christopher D.,He, Ming Y.,Liauw, Ann Y.,Woerner, Francis J.,Alexander, Richard S.,Knabb, Robert M.,Lam, Patrick Y. S.,Luettgen, Joseph M.,Wong, Pancras C.,Wright, Matthew R.,Wexler, Ruth R.
, p. 369 - 373 (2007/10/03)
Factor Xa (fXa) is an important serine protease that holds the central position linking the intrinsic and extrinsic activation mechanisms in the blood coagulation cascade. Therefore, inhibition of fXa has potential therapeutic applications in the treatmen
