209960-87-2

Upstream product

• 335275-88-2 C₂₅H₁₆F₄N₄OS 
• 209917-93-1 1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid 
• 209919-64-2 3-(5-(hydroxymethyl)-3-(trifluoromethyl )-1H-pyrazol-1-yl)benzonitrile 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 

Downstream Products

• 209957-47-1 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 385832-87-1 C₂₆H₁₉F₄N₇O₃S 
• 385832-89-3 C₂₆H₁₈F₄N₆O₃S₂ 
• 385832-82-6 C₂₆H₁₈F₄N₆O₄S 

Relevant academic research and scientific papers

NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli