209968-89-8

Basic information

• Product Name: Toluene-4-sulfonic acid (3aS,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-4-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester
• CAS NO: 209968-89-8
• Molecular Weight: 595.633
• Mol File: 209968-89-8.mol

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (3aS,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-4-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (3aS,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-4-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester(209968-89-8)
• EPA Substance Registry System: Toluene-4-sulfonic acid (3aS,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-4-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester(209968-89-8)

Safety Data

• Hazardous Substances Data: 209968-89-8(Hazardous Substances Data)

Upstream product

• 63592-90-5 N⁶-benzoyl-5'-hydroxymethyl-O^2'_,O3'-isopropylidene-adenosine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 209968-91-2 Toluene-4-sulfonic acid (2R,3R,3aS,9aS)-2-(6-benzoylamino-purin-9-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-dihydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-9a-ylmethyl ester 
• 209968-90-1 Toluene-4-sulfonic acid (2S,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3,4-dihydroxy-2-hydroxymethyl-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1]bicycle nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicycle nucleosides using a 4-C-tosyloxymethyl-1,2-di-O-acetyl furanose as a key synthon is described. In addition, an alternative, robust linear approach allowing selective formation of the desired [2.2.1]bicyclo LNA nucleosides via a tricyclic nucleoside intermediate is introduced.