209968-92-3

Upstream product

• 209968-90-1 Toluene-4-sulfonic acid (2S,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3,4-dihydroxy-2-hydroxymethyl-tetrahydro-furan-2-ylmethyl ester 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 63592-90-5 N⁶-benzoyl-5'-hydroxymethyl-O^2'_,O3'-isopropylidene-adenosine 
• 209968-91-2 Toluene-4-sulfonic acid (2R,3R,3aS,9aS)-2-(6-benzoylamino-purin-9-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-dihydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-9a-ylmethyl ester 

Downstream Products

• 209968-94-5 (1S,3R,4R,7S)-3-(6-N-benzoyladenine-9-yl)-7-hydroxy-1-hydroxymethyl-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1]bicycle nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicycle nucleosides using a 4-C-tosyloxymethyl-1,2-di-O-acetyl furanose as a key synthon is described. In addition, an alternative, robust linear approach allowing selective formation of the desired [2.2.1]bicyclo LNA nucleosides via a tricyclic nucleoside intermediate is introduced.