209971-43-7

Basic information

• Product Name: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE
• Synonyms: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE;N-(5-iodo-2-pyridinyl)-4-methylBenzenesulfonamide;N-(5-Iodo-Pyridin-2-Yl)-4-Methyl-Benzenesulfonamide(WX634020)
• CAS NO: 209971-43-7
• Molecular Formula: C₁₂H₁₁IN₂O₂S
• Molecular Weight: 374.2
• Mol File: 209971-43-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE(209971-43-7)
• EPA Substance Registry System: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE(209971-43-7)

Safety Data

• Hazardous Substances Data: 209971-43-7(Hazardous Substances Data)

Usage

General Description

N-(5-Iodo-pyridin-2-yl)-4-methyl-benzenesulfonamide, also known as MP-124, is a chemical compound that is commonly used in pharmaceutical research and development. It is a sulfonamide derivative with potential anti-inflammatory and analgesic properties. This chemical has been studied for its potential in the treatment of inflammation and pain-related conditions. It is also used as a building block in the synthesis of various pharmaceutical compounds. The compound's structure and properties make it a valuable tool for medicinal chemistry research and drug discovery efforts.

Upstream product

• 504-29-0 2-aminopyridine 
• 20511-12-0 2-amino-5-iodopyridine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 864866-52-4 N-(5-iodo-1-(3-oxopentan-2-yl)pyridin-2(1H)-ylidene)-4-methylbenzenesulfonamide 
• 209971-57-3 N-[3-(4-Chloro-phenylsulfanyl)-6-iodo-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide 
• 209971-49-3 2,2,2-trifluoro-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)acetamide 
• 504413-28-9 N-{6-[(2,6-dichloro-phenyl)-hydroxy-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide 
• 851916-81-9 N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide 

Relevant articles and documents

AROMATIC RING COMPOUND

The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K

PI3 kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation. The PI3 Kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations and PTEN p

Fragment based discovery of a novel and selective PI3 kinase inhibitor

We report the use of fragment screening and fragment based drug design to develop a PI3c kinase fragment hit into a lead. Initial fragment hits were discovered by high concentration biochemical screening, followed by a round of virtual screening to identify additional ligand efficient fragments. These were developed into potent and ligand efficient lead compounds using structure guided fragment growing and merging strategies. This led to a potent, selective, and cell permeable PI3c kinase inhibitor with good metabolic stability that was useful as a preclinical tool compound.