209971-50-6

Basic information

• Product Name: METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
• Synonyms: METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE;IMidazo[1,2-a]pyridine-6-carboxylic acid, 2-[(2,2,2-trifluoroacetyl)aMino]-, Methyl ester
• CAS NO: 209971-50-6
• Molecular Formula: C₁₁H₈F₃N₃O₃
• Molecular Weight: 287.19
• Mol File: 209971-50-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(209971-50-6)
• EPA Substance Registry System: METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(209971-50-6)

Safety Data

• Hazardous Substances Data: 209971-50-6(Hazardous Substances Data)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 209971-47-1 1-Carbamoylmethyl-6-[(E)-toluene-4-sulfonylimino]-1,6-dihydro-pyridine-3-carboxylic acid methyl ester 
• 1208250-24-1 methyl 1-(2-amino-2-oxoethyl)-6-(4-methylphenylsulfonamido)-1,6-dihydropyridine-3-carboxylate 
• 209971-44-8 6-[(Z)-Toluene-4-sulfonylimino]-1,6-dihydro-pyridine-3-carboxylic acid methyl ester 
• 36052-24-1 methyl 6-aminonicotinoate 

Downstream Products

• 209971-62-0 3-(4-Fluoro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 
• 209971-61-9 3-(4-Chloro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 
• 209971-64-2 3-(3-Chloro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 

Relevant articles and documents

cMET INHIBITORS

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Chemoselective arylsulfenylation of 2-aminoimidazo[1,2-α]pyridines by phenyliodine(III) bis(trifiuoroacetate) (PIFA)

A series of 2-(trifluoroacetamido)imidazo[1,2-a]pyridines was prepared and treated with phenyliodine(III) bis(trifluoroacetate) (PIFA) in the presence of a variety of thiols leading chemoselectively to the corresponding 3-sulfides. Exposure of these adducts to silica gel in MeOH/CH2Cl2 provides a convenient method for the cleavage of the trifluoroacetamide group.