209991-62-8

Basic information

• Product Name: 3,4,5-Trifluorophenylacetic acid
• Synonyms: RARECHEM AL BO 0708;3,4,5-TRIFLUOROPHENYLACETIC ACID;3,4,5-TRIFLUOROBENZENE ACETIC ACID;3,4,5-Trifluorobenzoic Acetic Acid;3,4,5-Trifluorophenylacetic acid 97%;3,4,5-Trifluorophenylaceticacid97%
• CAS NO: 209991-62-8
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.12
• Product Categories: Phenylacetic acid;Fluorine series
• Mol File: 209991-62-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 98-101℃
• Boiling Point: 254.6 °C at 760 mmHg
• Flash Point: 107.8 °C
• Appearance: /
• Density: 1.468 g/cm³
• Vapor Pressure: 0.00885mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.86±0.10(Predicted)
• CAS DataBase Reference: 3,4,5-Trifluorophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Trifluorophenylacetic acid(209991-62-8)
• EPA Substance Registry System: 3,4,5-Trifluorophenylacetic acid(209991-62-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 209991-62-8(Hazardous Substances Data)

Usage

Uses

3,4,5-Trifluorophenylacetic Acid is used in preparation of Pteridinone compounds for the treatment of cellular proliferative disorders.

InChI:InChI=1/C8H5F3O2/c9-5-1-4(3-7(12)13)2-6(10)8(5)11/h1-2H,3H2,(H,12,13)

Upstream product

• 238743-47-0 ethyl 2-(3,4,5-trifluorophenyl)acetate 

Downstream Products

• 1262106-34-2 2-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-(3,4,5-trifluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine 
• 1262106-94-4 2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole 
• 1262106-25-1 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-(3,4,5-trifluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine 
• 949166-97-6 5-chloro-2-(3,4,5-trifluorophenyl)pentanoic acid 
• 1191255-40-9 C₃₂H₂₇F₃N₄O₃ 
• 1123191-96-7 benzyl (3,4,5-trifluorophenyl)acetate 
• 1123192-11-9 2-(3,4,5-trifluorophenyl)-4-pentenoic acid 
• 849623-76-3 C₈H₄ClF₃O 
• 949167-77-5 4-chloro-2-(3,4,5-trifluorophenyl)butyric acid 
• 949560-37-6 1-amino-3-(3,4,5-trifluorophenyl)piperidin-2-one 

Relevant articles and documents

Preparation method of fluorophenylacetic acid

The invention relates to the field of chemical synthesis, and particularly relates to a preparation method of fluorophenylacetic acid. The invention provides a preparation method of fluorophenylacetic acid. The preparation method comprises the following steps: diazotization addition reaction: enabling a compound of the formula II to react in a system containing vinylidene chloride, acid, a diazonino reagent, a phase transfer catalyst and a copper catalyst to produce a compound of the formula III; and hydrolysis reaction: hydrolyzing the compound of the formula III to produce a compound of the formula I under the existence condition of acid. The preparation method is simply and easily available in raw materials, simple and convenient to operate, low in raw material cost, mild in reaction conditions, and low in danger, free from the use of high-price noble metal catalyst and complicated industrial operation means, and the quality of the product is stable, and therefore, the preparation method is suitable for industrial large-scale production.