21004-40-0

Upstream product

• 29108-14-3 2-Amino-4,5-dihydro-3-thiophencarbonsaeure-ethylester 
• 825-60-5 benzimidic acid ethyl ester 
• 51991-77-6 2-benzamido-4,5-dihydro-3-thiophenecarbonitrile 

Downstream Products

• 51959-99-0 4-chloro-2-phenyl-5,6-dihydrothieno<2,3-d>pyrimidine 
• 1022993-35-6 5,6-dihydro-4-methoxy-2-phenylthieno[2,3-d]pyrimidine 
• 1079042-24-2 5,6-dihydro-3-methyl-2-phenylthieno[2,3-d]pyrimidin-4(3H)-one 
• 51960-02-2 Cyclohexyl-(2-phenyl-5,6-dihydro-thieno[2,3-d]pyrimidin-4-yl)-amine 
• 51960-01-1 4-Morpholin-4-yl-2-phenyl-5,6-dihydro-thieno[2,3-d]pyrimidine 
• 51991-78-7 2-Phenyl-4-piperidin-1-yl-5,6-dihydro-thieno[2,3-d]pyrimidine 
• 51991-79-8 2-Phenyl-4-pyrrolidin-1-yl-5,6-dihydro-thieno[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis of 3-Acyl-5,6-dihydro-2-phenylthieno(-furo-)pyrimidin-4(3H)-ones

The reactions of 2-benzamido-4,5-dihydro-3-thiophene(-3-furan-)carbonitriles 1a-c (and 11a-c) with acetic (or propionic) anhydride in the presence of tin(IV) chloride give the corresponding 3-acetyl-5,6-dihydro-2-phenylthieno(-furo-)pyrimidin-4(3H)-ones 2a-c (and 12a-c) or 5,6-dihydro-2-phenyl-3-propionylthieno(-furo-)pyrimidin-4(3H)-ones 3a-c (and 13a-c).Hydrolysis of compounds 2a-c (and 12a-c) or 3a-c (and 13a-c) leads to the corresponding N-acetyl-2-benzamido-4,5-dihydro-3-thiophene-(-3-furan-)carboxamides 4a-c (and 14a-c) or 2-benzamido-4,5-dihydro-N-propionyl-3-thiophene-(-3-furan-) carboxamides 5a-c (and 15a-c).The reaction of compounds 4a,b (or 14a,b) with acid anhydrides in the presence of potassium carbonate or triethylamine gives the corresponding 3-acyl-2-benzamido-4,5-dihydrothiophenes (or furans) 9, 10, 16, and 17. - Key words: Thiophenes / Thienopyrimidines / Furans / Furopyrimidines

Studies on Heterocyclic Enaminonitriles. III. Reactions of 2-Benzamido-3-cyano-4,5-dihydrothiophenes with Amines

The reaction of 2-benzamido-3-cyano-4,5-dihydrothiophene (I) with cyclohexyllamine gave 4-cyclohexylamino-2-phenyl-5,6-dihydrothienopyrimidine (IVa) in 93percent yield.Similarly, I reacted with morpholine, piperidine and pyrrolidine to yield the co