210048-06-9

Basic information

• Product Name: (S)-2-(2-TERT-BUTOXY-2-OXOETHYL)-3,3-DIMETHYLBUTANOIC ACID
• Synonyms: (S)-2-(2-TERT-BUTOXY-2-OXOETHYL)-3,3-DIMETHYLBUTANOIC ACID
• CAS NO: 210048-06-9
• Molecular Formula: C₁₂H₂₂O₄
• Molecular Weight: 230.3
• Mol File: 210048-06-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-(2-TERT-BUTOXY-2-OXOETHYL)-3,3-DIMETHYLBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-TERT-BUTOXY-2-OXOETHYL)-3,3-DIMETHYLBUTANOIC ACID(210048-06-9)
• EPA Substance Registry System: (S)-2-(2-TERT-BUTOXY-2-OXOETHYL)-3,3-DIMETHYLBUTANOIC ACID(210048-06-9)

Safety Data

• Hazardous Substances Data: 210048-06-9(Hazardous Substances Data)

Upstream product

• 245323-37-9 (4S)-3-((2S)-4-(tert-butoxy)-2-(1,1-dimethylethyl)-4-oxobutanoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one 
• 104266-91-3 (S)-4-benzyl-3-(3,3-dimethylbutanoyl)oxazolidin-2-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 245323-43-7 S-ethyl (S)-4-(tert-butoxy)-2-(1,1-dimethylethyl)-4-oxobutanthioate 

Downstream Products

• 1001666-98-3 1-((2S,4R)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylic acid 
• 1001666-97-2 ethyl 1-((2S,4R)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate 
• 1001666-96-1 (3S)-3-((2S,4R)-2-(1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-1-carbonyl)-4,4-dimethylpentanoic acid 
• 1001667-23-7 (2S,4R)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(6-methoxy-3-phenylisoquinolin-1-yloxy)pyrrolidine-2-carboxamide 
• 1001666-95-0 C₄₁H₅₁N₃O₈ 
• 1001666-91-6 (3S)-3-((2S,4R)-2-(1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-1-carbonyl)-4,4-dimethylpentanoic acid 

Relevant articles and documents

A general method for the synthesis of enantiomerically pure β- substituted, β-amino acids through α-substituted succinic acid derivatives

A general procedure for the synthesis of enantiopure β-substituted, β- amino acids is presented. Alkylation of the sodium enolates derived from chiral N-acyloxazolidinone imides 2 (R = Me, i-Pr, t-Bu, Ph, Bn) with tert- butyl bromoacetate afforded the 2-substituted succinate derivatives 3 in good yields (82-89%) and with high selectivity (≥ 93;7). Following hydrolysis, Curtius rearrangement of the resulting carboxylic acid provided the enantiopure benzyloxycarbonyl (Cbz)-protected β-amino esters 6 in good yields (74-79%).