21017-46-9

Usage

General Description

3-[(4-Methoxyphenyl)amino]propanamide, also known as Mexiletine, is a chemical compound commonly used as a local anesthetic and antiarrhythmic medication. It works by blocking sodium channels in nerve cells, which helps to reduce pain sensations and manage irregular heart rhythms. Mexiletine is prescribed to treat chronic pain conditions such as neuropathic pain (nerve pain) and to control abnormal heartbeats in conditions like ventricular arrhythmia. It is an amide derivative of lidocaine and is available in oral capsule form for systemic use. Mexiletine is considered a valuable tool in managing chronic pain syndromes and cardiac arrhythmias and is typically well-tolerated by patients when used as directed by a healthcare professional.

InChI:InChI=1/C10H14N2O2/c1-14-9-4-2-8(3-5-9)12-7-6-10(11)13/h2-5,12H,6-7H2,1H3,(H2,11,13)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 79-06-1 2-propenamide 

Relevant academic research and scientific papers

Preparation method of 3-(phenyl amino)allylamines compound

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of a 3-(phenyl amino)allylamines compound. The method comprises the following stepsof mixing an aromatic amine compound and acrylamide, re

On-water magnetic NiFe2O4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

Here, we have demonstrated the Michael addition of active methylene compounds, aromatic/aliphatic amines, thiols and alcohols to conjugated alkenes using magnetic nano-NiFe2O4 as reusable catalyst in water. Nano-NiFe2O4 efficiently catalyzed the formation of C-C and C-X (X = N, S, O etc.) bond through 1,4-addition reactions.

Lithium tetrafluoroborate catalyzed highly efficient inter- and intramolecular aza-Michael addition with aromatic amines

Lithium tetrafluoroborate has been demonstrated for the first time to be an efficient catalyst in intermolecular aza-Michael addition aromatic amines to electron deficient alkenes. Suitability of the same catalyst in intramolecular aza-Michael addition leading 2-aryl-2,3-dihydroquinolin-4(1H) ones has also been described.