210222-18-7Relevant academic research and scientific papers
Synthesis of some new benzimidazoles bearing different heterocyclic moieties. Part III
Mahmoud,El-Ezbawy,El-Sherief,Sarhan, Abd El-Wareth A. O.
, p. 1155 - 1163 (2007/10/03)
Interaction of 2-(p-aminophenyl)benzimidazole (I) with chloroacetyl chloride afforded N-chloroacetyl derivative II which was also obtained from the cycloaddition reaction of chloroacetyl chloride to the Shiff's bases V a-f. Reaction of II with mercaptans and/or secondary amines gave IIIa-c and IVa-c, respectively. Condensation of I with aromatic aldehydes afforded Shiff's bases V a-f, which on cyclocondensation with mercaptoacetic acid gave 4-thiazolidinones VI a-f. Reaction of I with substituted isothiocyantes furnished thiourea derivatives VIII a-c, which condensed with chloroacetic acid or its ester to form thiazolidinones IX a-c. Arylidines XI a-f were obtained from the reaction of IX a-b and aromatic aldehydes. Cyclization of VIII a-c with phenacyl bromide or bromoacetone afforded thiazoline derivatives XII a-k.
