210236-57-0

Upstream product

• 210165-62-1 Dibenzyl-((1R,5S,6S)-3-benzyl-6-methoxy-3-aza-bicyclo[3.1.0]hex-6-yl)-amine 
• 210165-64-3 (1R,5S,6R)-6-Dibenzylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid methyl ester 
• 207790-97-4 1α,5α,6β-3-benzyl-6-dibenzylamino-3-azabicyclo[3.1.0]hexane 
• 210165-63-2 (1R,5S,6R)-6-Dibenzylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid vinyl ester 
• 210165-65-4 1α,5α,6β-6-dibenzylamino-3-azabicyclo[3.1.0]hexane 
• 210165-72-3 7-((1R,5S,6R)-6-Dibenzylamino-3-aza-bicyclo[3.1.0]hex-3-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 210165-61-0 Dibenzyl-(1-benzyl-3-chloro-1,2,3,6-tetrahydro-pyridin-4-yl)-amine 
• 164799-10-4 Dibenzyl-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-amine 

Downstream Products

• 146836-84-2 7-((1R,5S,6R)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; compound with methanesulfonic acid 

Relevant academic research and scientific papers

Diastereoselective syntheses of N-protected derivatives of 1α,5α,6β- 6-amino-3-azabicyclo[3.1.0]hexane; a route to trovafloxacin 6β-diastereomer

N-Protected derivatives 12, 13 and 17 of 1α,5α,6β-6-amino-3- azabicyclo[3.1.0]hexane 5 were synthesized via chloroenamines 6a or 6b. The specific N-protection was realized either by using a chloroenamine 6b with different protecting groups or by selective removal of identical protecting groups at the bicyclic target molecule 7. Dibenzylamino compound 13 allowed the preparation of naphthyridine derivative 25 which represents the 6β- diastereomer of trovafloxacin mesylate, a potent Gyrase inhibitor.