210304-58-8

Basic information

• Product Name: 3-[2-(dimethylamino)ethoxy]benzoic acid
• Synonyms: 3-[2-(dimethylamino)ethoxy]benzoic acid
• CAS NO: 210304-58-8
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.2417
• Mol File: 210304-58-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[2-(dimethylamino)ethoxy]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(dimethylamino)ethoxy]benzoic acid(210304-58-8)
• EPA Substance Registry System: 3-[2-(dimethylamino)ethoxy]benzoic acid(210304-58-8)

Safety Data

• Hazardous Substances Data: 210304-58-8(Hazardous Substances Data)

Upstream product

• 19438-10-9 methyl 3-hydroxybenzoate 

Relevant articles and documents

Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting PBD based on acyclic phosphopeptide PMQSpTPL. The inhibitory activities of 16e on Plk1-PBD is >30-fold higher than those of PMQSpTPL. Both 16a and 16e possess excellent selectivity for Plk1-PBD over Plk2/3-PBD. Analysis of the cocrystal structure of Plk1-PBD in complex with 16a reveals that the 3-(trifluoromethyl)benzoyl group in 16a interacts with Arg516 through a π-stacking interaction. This π-stacking interaction, which has not been reported previously, provides insight into the design of novel and potent Plk1-PBD inhibitors. Furthermore, 16h, a PEGlyated macrocyclic phosphopeptide derivative, induces Plk1 delocalization and mitotic failure in HeLa cells. Also, the number of phospho-H3-positive cells in a zebrafish embryo increases in proportion to the amount of 16a. Collectively, the novel macrocyclic peptidomimetics should serve as valuable templates for the design of potent and novel Plk1-PBD inhibitors.

Amide derivatives and intermediates for the synthesis thereof

Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon (α,γ)-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2 : each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3 : hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.