210345-02-1

Basic information

• Product Name: AC-LEU-GLU-THR-ASP-AFC
• Synonyms: AC-LEU-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN;AC-LEU-GLU-THR-ASP-AFC;AC-LETD-AFC;N-ACETYL-LEU-GLU-THR-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-Acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
• CAS NO: 210345-02-1
• Molecular Formula: C31H38F3N5O12
• Molecular Weight: 729.65
• Mol File: 210345-02-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: AC-LEU-GLU-THR-ASP-AFC(CAS DataBase Reference)
• NIST Chemistry Reference: AC-LEU-GLU-THR-ASP-AFC(210345-02-1)
• EPA Substance Registry System: AC-LEU-GLU-THR-ASP-AFC(210345-02-1)

Safety Data

• Hazardous Substances Data: 210345-02-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
AC-LEU-GLU-THR-AFC is used as a caspase-8 substrate for the study and evaluation of caspase-8 activity in various research and diagnostic applications. The cleavage of this peptide by caspase-8 results in the release of AFC (7-amino-4-trifluoromethylcoumarin), which can be detected and quantified using fluorescence measurements. This allows researchers to assess the activity of caspase-8 in cell samples, providing valuable insights into the apoptotic process and potential therapeutic targets for various diseases.
Used in Drug Development:
AC-LEU-GLU-THR-AFC is used as a tool in the development of new drugs targeting caspase-8 or the apoptotic pathway. By monitoring the cleavage of this peptide, researchers can evaluate the efficacy of potential drug candidates in modulating caspase-8 activity, which may have implications for the treatment of diseases characterized by dysregulated apoptosis, such as cancer or neurodegenerative disorders.
Used in Cell Signaling Research:
AC-LEU-GLU-THR-AFC is used as a research tool to study the role of caspase-8 in cell signaling pathways. The peptide can be employed in various assays to investigate the activation of caspase-8 under different conditions, such as in response to specific stimuli or in the presence of various signaling molecules. This information can be crucial for understanding the complex regulatory networks that govern cellular processes and may lead to the identification of novel therapeutic targets.
Used in Quality Control:
AC-LEU-GLU-THR-AFC is used as a quality control standard for the validation of caspase-8 activity assays. By including this peptide in assay protocols, researchers can ensure the accuracy and reliability of their measurements, which is essential for the reproducibility and comparability of experimental results across different studies and laboratories.