210345-04-3 Usage
Uses
Used in Pharmaceutical Research:
Z-LEHD-FMK is used as a research tool for studying the role of caspase-9 in apoptosis and its potential as a therapeutic target for various diseases. Its ability to inhibit caspase-9 provides insights into the underlying mechanisms of cell death and survival, which can be crucial in the development of new drugs and therapies.
Used in Drug Development:
Z-LEHD-FMK is used as a lead compound in the development of new drugs targeting caspase-9 for the treatment of diseases where apoptosis plays a significant role, such as cancer, neurodegenerative disorders, and autoimmune diseases. Its irreversible inhibition of caspase-9 can be exploited to design more potent and selective inhibitors with improved pharmacological properties.
Used in Cell Biology:
Z-LEHD-FMK is used as a reagent in cell biology experiments to modulate caspase-9 activity and investigate its effects on cellular processes, such as cell proliferation, differentiation, and survival. This can help researchers understand the complex interplay between caspase-9 and other cellular components in maintaining cellular homeostasis.
Used in Drug Delivery Systems:
In the context of drug delivery, Z-LEHD-FMK can be used as a component in the development of targeted drug delivery systems, such as nanoparticles or liposomes, to enhance the specificity and efficacy of caspase-9 inhibition in diseased cells. This can improve the therapeutic outcomes and reduce potential side effects associated with non-specific inhibition of caspase-9.
Biological Activity
Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo .
references
[1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.[3]. colak a, karao?lan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334.
Check Digit Verification of cas no
The CAS Registry Mumber 210345-04-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,3,4 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 210345-04:
(8*2)+(7*1)+(6*0)+(5*3)+(4*4)+(3*5)+(2*0)+(1*4)=73
73 % 10 = 3
So 210345-04-3 is a valid CAS Registry Number.
