210346-16-0

Basic information

• Product Name: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid
• Synonyms: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid;(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutyric acid;Boc-(S)-2-(aMinoMethyl)-3-Methylbutanoic acid;(S)-2-(((tert-Butoxycarbonyl)aMino)Methyl)-3-Methylbutanoic acid;(Tert-Butoxy)Carbonyl (S)-2-(Aminomethyl)-3-methylbutanoic acid
• CAS NO: 210346-16-0
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231
• Mol File: 210346-16-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 70-71 °C
• Boiling Point: 360.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.061±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.48±0.11(Predicted)
• CAS DataBase Reference: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(210346-16-0)
• EPA Substance Registry System: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(210346-16-0)

Safety Data

• Hazardous Substances Data: 210346-16-0(Hazardous Substances Data)

Usage

General Description

(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid, also known as Boc-protected amino acid, is a compound commonly used in peptide synthesis. It is a derivative of 3-methylbutanoic acid with a (2S) configuration and a tert-butoxycarbonyl (Boc) protecting group attached to the amino group. The Boc protecting group is used to prevent unwanted reactions during peptide synthesis, allowing for selective deprotection and further functionalization of the amino group. (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid is often used in the production of pharmaceuticals, bioconjugates, and other biologically active molecules, making it an important building block in organic and medicinal chemistry.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 203854-54-0 (2S)-([amino]methyl)-3-methylbutanoic acid 
• 27675-38-3 (E)-3-methyl-1-nitro-but-1-ene 
• 941292-85-9 (S)-tert-butyl 2-(hydroxymethyl)-3-methylbutylcarbamate 
• 903889-49-6 C₆H₁₅NO 

Downstream Products

• 1379661-63-8 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3-methyl-2-((piperidin-1-yl)methyl)butyl)thiourea 
• 200400-98-2 (S)-2-({(S)-3-[(S)-2-(tert-Butoxycarbonylamino-methyl)-3-methyl-butyrylamino]-butyrylamino}-methyl)-4-methyl-pentanoic acid benzyl ester 
• 631899-22-4 Boc-(S)-β²-HVal-(S)-β³-HPhe-OBn 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS SGC STIMULATORS

There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Enantioselective Friedel-Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

Enantioselective Friedel-Crafts reactions between phenols and N-tosylaldimines were developed using a bifunctional catalyst readily prepared from l-leucine. The chiral benzylic amine products were obtained in high yields (up to 96% yield) and good to high enantiomeric excesses (up to 95% ee).

New scalable asymmetric aminomethylation reaction for the synthesis of β2-amino acids

β-Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β2-amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O-acetals by Mannich-type iminium electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.