210352-22-0Relevant academic research and scientific papers
New expedient route to the stereoselective synthesis of fluorinated 1,3- diol derivatives via aluminum acetals derived from β-alkoxy esters and DIBAL
Ishihara, Takashi,Takahashi, Atsuya,Hayashi, Hidetoshi,Yamanaka, Hiroki,Kubota, Toshio
, p. 4691 - 4694 (1998)
On treating the aluminum acetal intermediates, generated in situ from ethyl 3-benzyloxy-2,2-difluoroalkanoates or 3-benzyloxy-4,4,4- trifluorobutanoate and diisobutylaluminum hydride at -78 °C for 1 h, with allylic stannanes in the presence of titanium(IV) dichloride diisopropoxide at 0 °C for 8 h or at -30 °C for 6 h, the corresponding allylated products, polyfluoro-1,3-diol derivatives, were obtained in good yields with high anti stereoselectivity.
