2104-66-7Relevant academic research and scientific papers
Supramolecular Helices via Self-Assembly of 8-Oxoguanosines
Giorgi, Tatiana,Lena, Stefano,Mariani, Paolo,Cremonini, Mauro A.,Masiero, Stefano,Pieraccini, Silvia,Rabe, Juergen P.,Samori, Paolo,Spada, Gian Piero,Gottarelli, Giovanni
, p. 14741 - 14749 (2003)
The cooperative effect of solvophobic interactions and hydrogen bonding has been exploited to self-assemble supramolecular helical architectures of 8-oxoguanosines in different environments. This self-assembly into helical structures is completely different from that of the parent guanosines which, in the same experimental conditions, form flat, ribbonlike structures. While optical microscopy and X-ray diffraction suggest a chiral columnar aggregate in the LC phase, NMR and Circular Dichroism reveal the presence of a helical structures in solution. Scanning Tunneling Microscopy made it possible to visualize hexagonally arranged G-quartets on graphite, which are sections of the helices packed with their long axis perpendicular to the basal plane of the substrate. Due to their rectifying electrical properties, such helices are interesting for fabricating (opto)electronic biodevices.
Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway
Chen, Fu,Davis, Jeffery T.,Gutierrez, Osvaldo,Lee, Wes,Xiao, Songjun,Zavalij, Peter Y.
supporting information, p. 6981 - 6984 (2020/07/14)
A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S-S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine. This journal is
Chikungunya virus inhibition by synthetic coumarin–guanosine conjugates
Hwu, Jih Ru,Huang, Wen-Chieh,Lin, Shu-Yu,Tan, Kui-Thong,Hu, Yu-Chen,Shieh, Fa-Kuen,Bachurin, Sergey O.,Ustyugov, Alexey,Tsay, Shwu-Chen
, p. 136 - 143 (2019/01/30)
Since its discovery in Tanganyika, Africa in 1952, chikungunya virus (CHIKV) outbreaks have occurred in Africa, Asia, Europe, and America. Till now chikungunya fever has spread in nearly 40 countries. Because of lack of effective vaccines and antiviral dr
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells
Lin,Cheng,Ishiguro,Sartorelli
, p. 1194 - 1198 (2007/10/02)
A variety of 8-substituted guanosine and 2'-deoxyguanosine derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells in culture. The most active agents in the guanosine series were 8-substituted -N(CH3)2, -NHCH3, -NH2, -OH, and -SO2CH3, which caused 68, 42, 34, 33, and 30% of erythroleukemia cells to attain benzidine positivity, a functional measure of maturation, at concentrations of 5, 1, 0.4, 5, and 5 mM, respectively. The 8-OH derivative of the 2'-deoxyguanosine series produced comparable activity, causing 62% benzidine-positive cells at a level of 0.2 mM. These findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells.
