2104-66-7Relevant articles and documents
Supramolecular Helices via Self-Assembly of 8-Oxoguanosines
Giorgi, Tatiana,Lena, Stefano,Mariani, Paolo,Cremonini, Mauro A.,Masiero, Stefano,Pieraccini, Silvia,Rabe, Juergen P.,Samori, Paolo,Spada, Gian Piero,Gottarelli, Giovanni
, p. 14741 - 14749 (2003)
The cooperative effect of solvophobic interactions and hydrogen bonding has been exploited to self-assemble supramolecular helical architectures of 8-oxoguanosines in different environments. This self-assembly into helical structures is completely different from that of the parent guanosines which, in the same experimental conditions, form flat, ribbonlike structures. While optical microscopy and X-ray diffraction suggest a chiral columnar aggregate in the LC phase, NMR and Circular Dichroism reveal the presence of a helical structures in solution. Scanning Tunneling Microscopy made it possible to visualize hexagonally arranged G-quartets on graphite, which are sections of the helices packed with their long axis perpendicular to the basal plane of the substrate. Due to their rectifying electrical properties, such helices are interesting for fabricating (opto)electronic biodevices.
Chikungunya virus inhibition by synthetic coumarin–guanosine conjugates
Hwu, Jih Ru,Huang, Wen-Chieh,Lin, Shu-Yu,Tan, Kui-Thong,Hu, Yu-Chen,Shieh, Fa-Kuen,Bachurin, Sergey O.,Ustyugov, Alexey,Tsay, Shwu-Chen
, p. 136 - 143 (2019/01/30)
Since its discovery in Tanganyika, Africa in 1952, chikungunya virus (CHIKV) outbreaks have occurred in Africa, Asia, Europe, and America. Till now chikungunya fever has spread in nearly 40 countries. Because of lack of effective vaccines and antiviral dr
