Tosyllysine chloromethyl ketone (TLCK) is a chemical compound with the formula C21H25ClN2O4S. It is a potent and irreversible inhibitor of serine proteases, a class of enzymes that play a crucial role in various biological processes, including digestion, blood clotting, and immune response. TLCK works by covalently modifying the active site serine residue in these enzymes, thereby preventing their catalytic activity. Tosyllysine chloromethyl ketone is commonly used in biochemical research to study the function and regulation of serine proteases, as well as in the development of therapeutic agents targeting these enzymes. Due to its reactivity, TLCK is typically handled with care in a laboratory setting to avoid unwanted side reactions or toxicity.

2104-86-1

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Basic information
1. Product Name: Tosyllysine chloromethyl ketone
2. Synonyms: Tosyllysine chloromethyl ketone
3. CAS NO:2104-86-1
4. Molecular Formula: C14H21ClN2O3S
5. Molecular Weight: 332.84614
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 2104-86-1.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 509.8°C at 760 mmHg
3. Flash Point: 262.1°C
4. Appearance: /
5. Density: 1.242g/cm³
6. Vapor Pressure: 1.65E-10mmHg at 25°C
7. Refractive Index: 1.545
8. Storage Temp.: N/A
9. Solubility: N/A
10. PKA: 8.52±0.50(Predicted)
11. CAS DataBase Reference: Tosyllysine chloromethyl ketone(CAS DataBase Reference)
12. NIST Chemistry Reference: Tosyllysine chloromethyl ketone(2104-86-1)
13. EPA Substance Registry System: Tosyllysine chloromethyl ketone(2104-86-1)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 2104-86-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 2104-86-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,0 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2104-86:
(6*2)+(5*1)+(4*0)+(3*4)+(2*8)+(1*6)=51
51 % 10 = 1
So 2104-86-1 is a valid CAS Registry Number.

InChI:InChI=1/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3

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