210405-62-2

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 136159-63-2 N-(t-butyloxycarbonyl)-N-benzylaminoacetaldehyde 
• 121496-39-7 N-(tert-butoxycarbonyl)-N-benzylethanolamine 
• 104-63-2 N-Benzylethanolamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 210405-61-1 4-(N-benzyl-N-tert-butoxy-carbonylamino)but-2-enal 
• 210405-79-1 4-(N-benzyl-N-tert-butoxy-carbonylamino)but-2-en-1-ol 

Relevant academic research and scientific papers

Enantioselective synthesis of 1,2-, 1,3- and 1,4- aminoalcohols by the addition of dialkylzincs to 1,2-, 1,3- and 1,4- aminoaldehydes

Chiral 1,3- and 1,4- aminoalcohols were prepared by the addition of functionalized dialkylzincs to 1,3-aliphatic and 1,4-unsaturated aminoaldehydes with good to excellent enantioselectivity. Syn- or anti-1,2- aminoalcohols are stereoselectively obtained by asymmetric addition of dialkylzincs to α-aminoaldehydes depending on the choice of the chiral catalyst. A chelate controlled addition is observed if less than stoichiometric amounts of Ti(Oi-Pr)4 are used.