210415-79-5Relevant academic research and scientific papers
A short synthesis of γ-amino acids from nitrones; synthesis of Vigabatrin
Dagoneau,Tomassini,Denis,Vallée
, p. 150 - 154 (2001)
Treatment of the γ-N-hydroxylamino-α,β-acetylenic esters, obtained by the reaction of nitrones with alkyl 3-lithiopropiolates, with H2 over Raney nickel, followed by in situ protection of the formed amines, gives N-Boc-γ-amino esters. This meth
Ready access to enantiopure 5-substituted-3-pyrrolin-2-ones from N- benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone (BIGN)
Merino, Pedro,Castillo, Elena,Franco, Santiago,Merchan, Francisco L.,Tejero, Tomas
, p. 1759 - 1769 (2007/10/03)
The reaction of the lithiated salt of methyl propiolate with N-benzyl- 2,3-O-isopropylidene-D-glyceraldehyde nitrone (BIGN) afforded the corresponding propargyl hydroxylamines in a stereocontrolled way depending on the nature of the Lewis acid used as an additive. Subsequent reduction of the obtained hydroxylamines provided chiral 5-substituted-3-pyrrolin-2-ones, in high overall yields.
