210424-87-6Relevant academic research and scientific papers
An efficient synthesis of futalosine
Li, Xu,Tanner, Martin E.
supporting information; experimental part, p. 6463 - 6465 (2010/12/25)
Futalosine is a naturally occurring nucleoside comprised of an inosine core with a 3-carboxyphenyl methylene ketone functionality replacing the C-5′ hydroxyl. Recent studies have shown that it is a key intermediate in an alternative biosynthetic pathway that generates menaquinone in a variety of bacterial species. Here we report the first synthesis of futalosine in seven steps from inosine in an overall 17% yield. This work will enable further studies on menaquinone biosynthesis in pathogenic bacteria.
