210472-45-0

Upstream product

• 210472-43-8 methyl 3,6-di-O-acetyl-2-azido-2-deoxy-β-D-galactopyranoside 
• 87376-50-9 (2R,3R,4R,5R,6R)-5-azido-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4-diol 
• 290819-66-8 methyl 2-acetamido-3,6-di-O-benzoyl-2,4-dideoxy-4-fluoro-β-D-glucopyranoside 
• 3946-01-8 methyl N-acetyl-β-D-glucosaminide 
• 176690-92-9 methyl 2-acetamido-3,6-di-O-benzoyl-2-deoxy-4-O-trifluormethanesulfonyl-β-D-galactopyranoside 
• 176690-91-8 methyl 2-acetamido-3,6-di-O-benzoyl-2-deoxy-β-D-galactopyranoside 
• 176690-90-7 methyl 2-acetamido-3,6-di-O-benzoyl-2-deoxy-β-D-glucopyranoside 
• 108-24-7 acetic anhydride 
• 210472-05-2 methyl 2-acetamido-2,4-dideoxy-4-fluoro-β-D-glucopyranoside 
• 210472-44-9 methyl 3,6-di-O-acetyl-2-azido-2,4-dideoxy-4-fluoro-β-D-glucopyranoside 

Relevant academic research and scientific papers

Synthesis of 4-deoxy-4-fluoro analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-galactose and their effects on cellular glycosaminoglycan biosynthesis

4-Deoxy-4-fluoro analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-galactose were synthesized and evaluated as inhibitors of hepatic glycosaminoglycan biosynthesis. 2-Acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-4-fluoro-D-glucopyranose (16) exhibited a reduction of [3H]GlcN and [35S]SO4 incorporation into hepatocyte cellular glycosaminoglycans to 12 and 18%, respectively, of the control cells, at 1.0 mM. Similarly, 2-acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-4-fluoro-D-galactopyranose (31) exhibited a reduction of [3H]GlcN and [35S]SO4 incorporation to 1 and 9%, respectively, of the control cells, at 1.0 mM. Unlike 16, 31 exhibited a reduction of [14C]Leu incorporation into cellular protein to 57% of control cells, at 1.0 mM. Copyright (C) 2000 Elsevier Science Ltd.

Novel features of acceptor recognition by β-(1 ← 4)- galactosyltransferase

In order to understand how β-(1→4)-galactosyltransferase recognizes its glycosyl acceptor, substrate specificities were investigated using synthetic 2-acetamido-2-deoxy-D-glucopyranose (N-acetylglucosamine) derivatives in which the 1-, 2-, 3-, 4-, and 6-p