2105-86-4Relevant academic research and scientific papers
Method for preparing amine compound by reducing amide compound
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Paragraph 0117-0119, (2021/02/10)
The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.
Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines
Das, Suman,Karmakar, Himadri,Bhattacharjee, Jayeeta,Panda, Tarun K.
, p. 11978 - 11984 (2019/08/13)
We report an efficient protocol for the catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to afford the corresponding amines in high yields using aluminium complexes [κ2-{Ph2P(X)NC9H6N}Al(Me)2] [X = S (2a), Se (2b)] as pre-catalysts at room temperature. The aluminium complexes were prepared from the reaction of [Ph2P(X)NC9H6N] [X = S (1a), Se (1b)] and trimethylaluminium in toluene. The solid-state structure of complex 2b is established. Tertiary amides with a wide array of electron-withdrawing and electron-donating functional groups were easily converted to the desired products through the selective cleavage of the amides' CO bond by aluminium hydride as an active species. A kinetic study of the catalytic reaction is also reported.
