210532-25-5

Basic information

• Product Name: 3,5-DIFLUOROBENZENESULFONYL CHLORIDE
• Synonyms: 3,5-DIFLUOROBENZENESULFONYL CHLORIDE;3,5-DIFLUOROBENZENESULPHONYL CHLORIDE;BUTTPARK 27\07-03;Benzenesulfonyl chloride, 3,5-difluoro- (9CI);3,5-Difluorobenzenesulphonyl chloride 97%;3,5-Difluorobenzenesulphonylchloride97%;3,5-difluorobenzenesulfonyl chloride(SALTDATA: FREE);3,5-Difluorobenzenesulfonyl chloride,97%
• CAS NO: 210532-25-5
• Molecular Formula: C₆H₃ClF₂O₂S
• Molecular Weight: 212.6
• EINECS: -0
• Product Categories: SULFONYLHALIDE;Aromatic Halides (substituted);Benzenesulfonyl chloride;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Fluorine series
• Mol File: 210532-25-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 57-59°C
• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: Orange to tan/Crystalline Powder
• Density: 1.58 g/cm³
• Vapor Pressure: 0.0922mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 8053561
• CAS DataBase Reference: 3,5-DIFLUOROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIFLUOROBENZENESULFONYL CHLORIDE(210532-25-5)
• EPA Substance Registry System: 3,5-DIFLUOROBENZENESULFONYL CHLORIDE(210532-25-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 210532-25-5(Hazardous Substances Data)

Usage

Chemical Properties

Tan or orange solid

Uses

3,5-Difluorobenzenesulfonyl chloride may be used to synthesize the following:N,N-diethyl-3,5-difluorobenzene sulfonamide N-phenyl-3,5-difluorobenzene sulfonamideIt can be used for the regioselective monosulfonation of methyl-α-D-glucopyranoside.

InChI:InChI=1/C6H3ClF2O2S/c7-12(10,11)6-2-4(8)1-5(9)3-6/h1-3H

Upstream product

• 372-39-4 3,5-difluoroaniline 

Downstream Products

• 1372794-94-9 N,N-diethyl-3,5-difluorobenzenesulfonamide 
• 1399292-80-8 phenyl 2-O-(3,5-difluorobenzensulfonyl)-α-D-glucopyranoside 
• 1399292-77-3 octyl 2-O-(3,5-difluorobenzensulfonyl)-α-D-glucopyranoside 
• 1399293-53-8 methyl 3-O-(3,5-difluorobenzensulfonyl)-α-L-rhamnopyranoside 
• 1399293-50-5 methyl 3-O-(3,5-difluorobenzensulfonyl)-β-L-fucopyranoside 
• 1399293-47-0 methyl 3-O-(3,5-difluorobenzensulfonyl)-α-L-fucopyranoside 
• 1399293-44-7 methyl 4-O-(3,5-difluorobenzensulfonyl)-β-D-xylopyranoside 
• 1399293-35-6 methyl 3-O-(3,5-difluorobenzensulfonyl)-α-D-galactopyranoside 
• 1399293-29-8 methyl 3-O-(3,5-difluorobenzensulfonyl)-α-D-mannopyranoside 
• 1399292-74-0 methyl 2-O-(3,5-difluorobenzenesulfonyl)-α-D-glucopyranoside 
• 1399292-86-4 ethyl 2-O-(3,5-difluorobenzensulfonyl)-α-D-thioglucopyranoside 
• 1399292-83-1 4-nitrophenyl 2-O-(3,5-difluorobenzensulfonyl)-α-D-glucopyranoside 
• 1392150-34-3 N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide 
• 1392150-35-4 N-(6-chloro-5-cyanopyridin-3-yl)-3,5-difluorobenzene-sulfonamide. 

Relevant articles and documents

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Fluorine NMR studies of the human carbonic anhydrase-3,5-difluorobenzenesulfonamide complex

Fluorine and nitrogen-15 NMR experiments are described which show that 3,5-difluorobenzene-sulfonamide binds to human carbonic anhydrase I in a 1:1 complex, that the bound inhibitor is present as an anion and that the aromatic ring of the inhibitor underg