210545-36-1

Basic information

• Product Name: 1-Benzyl-5-(3,4-dichloro-phenyl)-5-(3-hydroxy-propyl)-piperidin-2-one
• CAS NO: 210545-36-1
• Molecular Weight: 392.325
• Mol File: 210545-36-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-5-(3,4-dichloro-phenyl)-5-(3-hydroxy-propyl)-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-5-(3,4-dichloro-phenyl)-5-(3-hydroxy-propyl)-piperidin-2-one(210545-36-1)
• EPA Substance Registry System: 1-Benzyl-5-(3,4-dichloro-phenyl)-5-(3-hydroxy-propyl)-piperidin-2-one(210545-36-1)

Safety Data

• Hazardous Substances Data: 210545-36-1(Hazardous Substances Data)

Upstream product

• 210545-35-0 1-Benzyl-5-(3,4-dichloro-phenyl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-piperidin-2-one 
• 146395-96-2 2-(3,4-dichloro-phenyl)-5-(tetrahydro-pyran-2-yl-oxy)-pentanenitrile 
• 146395-97-3 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid ethyl ester 
• 146395-98-4 5-tetrahydropyranyloxypropyl-5-(3,4-dichlorophenyl)piperidone 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 210545-37-2 Methanesulfonic acid 3-[1-benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piperidin-3-yl]-propyl ester 

Relevant articles and documents

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1

We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the 125I-[MIP-1β] binding and Ba-L-HOS antiviral assays resulted in the discovery of 64 and 68 in the 4,4-disubstitited piperidine class H, both potent CCR5 ligands (pIC50 = 8.30 and 9.00, respectively) and HIV-1 inhibitors (pIC50 = 7.80 and 7.84, respectively, in Ba-L-HOS assay). In addition, 64 and 68 were bioavailable in rodents, establishing them as lead molecules for further optimization toward CCR5 clinical candidates.