210558-22-8Relevant academic research and scientific papers
Synthesis of some new 3-(chlorophenyl)isocoumarins and their conversion to 3,4-dihydro derivatives
Rama, Nasim H.,Iqbal,Rauf,Rao, Muhammad I.,Zamani,Raza, Abdul R.
, p. 338 - 341 (2007/10/03)
Condensation of homophthalic acid 4 with chlorobenzoyl chlorides 5a-c yields 3-(chlorophenyl)isocoumarins 6a-c which on alkaline hydrolysis give the keto-acids 7a-c. (dl)-3-(Chlorophenyl)-3,4-dihydroisocoumarins 10a-c have been obtained by the reduction of 7a-c to racemic hydroxyacids 9a-c followed by cyclodehydration using acetic anhydride.
