210561-38-9

Upstream product

• 50-00-0 formaldehyd 
• 18942-49-9 Boc-D-Phe-OH 

Downstream Products

• 1356265-48-9 C₁₄H₁₆ClNO₄ 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 
• 210561-40-3 Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 210561-39-0 (R)-4-Benzyl-5-hydroxy-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

An l-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda-Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein. The Royal Society of Chemistry 2012.

N-hydroxymethyl group for configurationally stable N-alkoxycarbonyl α- amino aldehydes [1]

Attachment of an N-hydroxymethyl group to N-Boc-α-amino aldehyde enhanced greatly the configurational stability of the stereogenic carbon α to the aldehyde group by shifting the equilibrium from an open form of ω- hydroxyaldehyde to a closed form of hemiacetal. The N-hydroxymethyl group was introduced by treating N-Boc-α-amino acids with formaldehyde in the presence of an acid catalyst followed by reduction with DIBALH.