210571-49-6Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
Balzarini, Jan,Bortolozzi, Roberta,Brancale, Andrea,Ferla, Salvatore,Hamel, Ernest,Kimatrai Salvador, Maria,Liekens, Sandra,Oliva, Paola,Persoons, Leentje,Prencipe, Filippo,Romagnoli, Romeo,Schols, Dominique,Viola, Giampietro
, (2020/02/22)
A new class of inhibitors of tubulin polymerization based on the 2-alkoxycarbonyl-3-(3′,4′,5′-trimethoxyanilino)indole molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle eff
Interleukin-4 gene expression inhibitors
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, (2008/06/13)
This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R1, R2 and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
