21059-40-5Relevant academic research and scientific papers
SYNTHESIS OF A SCAFFOLD FOR THE CREATION OF NON-PEPTIDE LIBRARIES
Kasal, Alexander,Kohout, Ladislav,Lebl, Michal
, p. 2147 - 2155 (1995)
5β-Cholanic acid derivative XVII was prepared as a skeleton for the creation of non-peptide libraries.In positions 3, 7 and 12, different functional groups were designed in order to provide for the attachment of various building blocks linked to them.
Preparation of radiolabelled 3α-hydroxy-7-keto-5β-cholanic acid and its glycine and taurine conjugates
Carlson,Fromm
, p. 421 - 434,423,428 (2007/10/13)
3α-Hydroxy-7-keto-5β-cholanic acid has been prepared from cholic acid by a route which allowed introduction of 3H into positions 11 and 12 of the steroid C ring. Labelling with 14C was done by halodecarboxylation and resynthesis of the carboxyl function with 14C cyanide. The conjugates of both 3H- and 14C-labelled compounds with glycine and taurine were prepared. 14C-labelled compounds were prepared by degradation of the carboxyl-containing side chain to the norchloride, which was used to prepare the homologous 14C-containing nitrile. Hydrolysis afforded the acid in good yield. 3H was introduced into the C ring of the steroid nucleus by dehydration of 3α,12α-dihydroxy-7-keto-5β-cholanic acid to the Δ11-alkene which was catalytically tritiated. Physical and spectral data are presented to characterize the new compounds and TLC methods for purification are reported.
