210690-98-5Relevant academic research and scientific papers
Intermediates for the synthesis of epothilones and methods for their preparation
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Page column 29, (2010/01/30)
The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3and X4are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.
Total synthesis of (-)-epothilone A
Schinzer, Dieter,Bauer, Armin,Boehm, Oliver M.,Limberg, Anja,Cordes, Martin
, p. 2483 - 2491 (2007/10/03)
The total synthesis of (-)-epothilone A by a convergent route is reported. The synthesis of the required key intermediates has been improved with respect to stereoselectivity and availability. The access to ethyl ketone 2 has been significantly improved b
