210692-60-7

Upstream product

• 83-01-2 diphenylcarbamic chloride 
• 157848-06-1 4-amino-5,7-dichloro-quinoline-2-carboxylic acid methyl ester 
• 20843-48-5 methyl 5,7-dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylate 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 626-43-7 3,5-Dichloroaniline 
• 106509-94-8 (E)-2-(3,5-Dichloro-phenylamino)-but-2-enedioic acid dimethyl ester 

Relevant academic research and scientific papers

QUINOLINE-UREA DERIVATIVES FOR THE TREATMENT OF WITHDRAWAL SYNDROME AND WITHDRAWAL-INDUCED BRAIN DAMAGE

Compounds, compositions and method for ameliorating alcohol or drug dependency withdrawal syndromes and withdrawal-induced brain damage are disclosed. In particular, a series of N-substituted-4-ureido-5,7-dihalo-2-carboxy quinoline compounds are disclosed

Novel structure having antagonist actions at both the glycine site of the N-methyl-D-aspartate receptor and neuronal voltage-sensitive sodium channels: Biochemical, electrophysiological, and behavioral characterization

A novel series of N-substituted 4-ureido-5,7-dichloro-quinolines were synthesized to contain pharmacophores directed at voltage-sensitive sodium channels (VSNaCs) and N-methyl-D-aspartate (NMDA) receptors. These compounds were shown to act in a use-dependent manner as antagonists of VSNaCs and to act as selective competitive antagonists at the strychnine-insensitive glycine recognition site of NMDA receptors. These agents had little or no effect on α-adrenergic receptors, other glutamate receptors, or sites other than the glycine site on the NMDA receptor, and did not block voltage- sensitive calcium channels in vitro. In vivo, the compounds were active in preventing or reducing the signs and symptoms of neurohyperexcitability and had anxiolytic properties. Unlike benzodiazepines, N-substituted 4-ureido- 5,7-dichloro-quinolines showed little interaction with the sedative effects of ethanol, but were effective in controlling ethanol withdrawal seizures. The combined actions of these compounds on VSNaCs and NMDA receptors also impart properties to these compounds that are important for preventing and reducing excitotoxic neurodegeneration, but these compounds lack the undesirable side effects of other agents used for these purposes.