2107-39-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Trifluoromethyl-1H-benzimidazole-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its potential bioactivity. Its electronegative and hydrophobic properties contribute to the development of drugs with improved pharmacokinetic and pharmacodynamic profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Trifluoromethyl-1H-benzimidazole-2-carboxylic acid is utilized as a building block for the creation of novel agrochemicals. Its unique chemical properties allow for the design of compounds with enhanced pesticidal or herbicidal activities.
Used in Anticancer Research:
5-Trifluoromethyl-1H-benzimidazole-2-carboxylic acid is employed as a potential anticancer agent in research settings. Its bioactivity suggests that it may have the capacity to target and inhibit the growth of cancer cells, making it a promising candidate for further investigation and development in oncology.
Used in Antiviral Research:
As an antiviral agent, 5-Trifluoromethyl-1H-benzimidazole-2-carboxylic acid is explored for its potential to inhibit viral replication and infectivity. Its electronegative nature may allow it to interfere with viral processes, offering a new avenue for antiviral drug development.
Used in Medicinal Chemistry Research:
In medicinal chemistry, 5-Trifluoromethyl-1H-benzimidazole-2-carboxylic acid serves as a versatile compound for the study of structure-activity relationships. Its unique structural features provide a foundation for the design and optimization of new therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C9H5F3N2O2/c10-9(11,12)4-1-2-5-6(3-4)14-7(13-5)8(15)16/h1-3H,(H,13,14)(H,15,16)

Upstream product

• 673487-33-7 2-trichloromethyl-6-trifluoromethyl-1H-benzoimidazole 
• 673487-33-7 2-trichloromethyl-5-trifluoromethyl-1H-benzoimidazole 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 

Relevant academic research and scientific papers

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound represented by the following Formula (1) The compounds indicated by formula (1) are used to promote the growth of plants. A pla

CARBAMATE COMPOUND OR SALT THEREOF

[Problems] A compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases is provided. [Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that a piperazine-1-carboxylate compound, in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl or the like binds to the 4-position of the piperazine, has an excellent FAAH inhibitory activity and further has an action to increase the effective bladder capacity, an action to ameliorate sleep disorders, an anti-diuretic action, and an analgesic activity on lower urinary tract pain including bladder pain and the like, thereby completed the present invention. The carbamate compound of the present invention has an excellent FAAH inhibitory activity and can be used as an agent for preventing and/or treating FAAH-related diseases, particularly nocturia, interstitial cystitis, painful bladder syndrome, or chronic non-bacterial prostatitis/chronic pelvic pain syndrome.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

BENZIMIDAZOLE CARBOXAMIDES AS RAF KINASE INHIBITORS

The present invention relates to benzimidazole carboxamides of formula (I), the use of the compounds of formula (I) as inhibitors of as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula (I) or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase phathways, preferably by the raf kinase pathway, especially cancers.