210702-79-7

Basic information

• Product Name: β ethyl 2-deoxy-L-ribofuranoside
• Synonyms: β ethyl 2-deoxy-L-ribofuranoside
• CAS NO: 210702-79-7
• Molecular Weight: 162.186
• Mol File: 210702-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: β ethyl 2-deoxy-L-ribofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: β ethyl 2-deoxy-L-ribofuranoside(210702-79-7)
• EPA Substance Registry System: β ethyl 2-deoxy-L-ribofuranoside(210702-79-7)

Safety Data

• Hazardous Substances Data: 210702-79-7(Hazardous Substances Data)

Upstream product

• 18546-37-7 2-deoxy-L-ribose 

Downstream Products

• 141846-57-3 3,5-di-O-(4-methylbenzoyl)-2-deoxy-α-L-erythro-pentofuranosyl chloride 

Relevant articles and documents

Synthesis of beta-L-2'-deoxy nucleosides

An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.