210704-86-2Relevant academic research and scientific papers
3-Amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors
Sanderson, Philip E. J.,Cutrona, Kellie J.,Savage, Kelly L.,Naylor-Olsen, Adel M.,Bickel, Denise J.,Bohn, Dennis L.,Clayton, Franklin C.,Krueger, Julie A.,Lewis, S. Dale,Lucas, Bobby J.,Lyle, Elizabeth A.,Wallace, Audrey A.,Welsh, Denice C.,Yan, Youwei
, p. 1441 - 1444 (2003)
We describe a series of highly potent and efficacious thrombin inhibitors based on a 3-amino-4-sulfonylpyridinone acetamide template. The functionally dense sulfonyl group stabilizes the aminopyridinone, conformationally constrains the 4-substituent, and
