210710-86-4Relevant academic research and scientific papers
Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors
Sheppard, George S.,Florjancic, Alan S.,Giesler, Jamie R.,Xu, Lianhong,Guo, Yan,Davidsen, Steven K.,Marcotte, Patrick A.,Elmore, Ildiko,Albert, Daniel H.,Magoc, Terrance J.,Bouska, Jennifer J.,Goodfellow, Carole L.,Morgan, Douglas W.,Summers, James B.
, p. 3251 - 3256 (2007/10/03)
A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C- terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several comp
