21074-63-5Relevant academic research and scientific papers
Novel synthesis of dihydroxanthyletin and dihydroseselin derivatives
Jetter,Heindel,Laskin
, p. 995 - 997 (1990)
In a one-step alkylation, ring-closure 7-hydroxycoumarins are condensed in acid media with allyl and homoallyl halides or alcohols to linear 6,7-dihydro-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-ones. If both carbon-6 and carbon-8 are unsubstituted in the original coumarin, cyclization to angular isomers 9,10-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-2- ones competes. These compounds are higher ring homologs of psoralens and angelicins commonly employed in phototherapy of skin disorders.
A simple and efficient approach for the preparation of dihydroxanthyletin, xanthyletin, decursinol and marmesin
Kommera, Rajkumar,Bhimapaka, China Raju
, p. 3204 - 3211 (2020/08/05)
A simple and efficient approach has been developed for the preparation of coumarin natural products such as dihydroxanthyletin, xanthyletin, decursinol and marmesin starting from commercially available 2,4-dihydroxybenzaldehyde with very good yields. Wittig homologation and Claisen rearrangement are the protocols used to achieve these molecules.
