21078-03-5Relevant academic research and scientific papers
A short, vinyl radical cyclisation approach to (±))-2-pupukeanone
Srikrishna,Vijaykumar,Sharma
, p. 2003 - 2004 (1997)
Addition of tri-n-butyltin radical to a 5-(prop-2-ynyl)bicyclo [2.2.2]oct-2-ene followed by 5-exo-trig cyclisation of the resulting vinyl radical furnishes an isotwistane, providing a short route to the sesquiterpenes, pupukeananes 4 and 2.
Gold(I)-Catalyzed Allene–Diene–Alkyne Coupling Reaction to Polycycles
Haberhauer, Gebhard,Kreuzahler, Mathis,Semleit, Nina
, p. 6629 - 6634 (2020)
In general, the design of complex polycycles from simple building blocks is challenging and requires many reaction steps. Herein, we present that complex polycycles can be synthesized starting from two alkyne building blocks in a one-pot reaction using go
Method for synthesizing mexiletine chloride
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Paragraph 0031; 0032; 0033; 0034, (2019/03/15)
The invention discloses a method for synthesizing mexiletine chloride, wherein a reaction system takes 2,6-xylenol as a starting material to synthesize a corresponding target product. In the reaction,a transition metal gold complex and a ruthenium complex are used for catalysis, compared with the previous method for synthesizing mexiletine chloride, no alkali is added during a reaction process, no by-products are produced, the reaction atom economy is high, and the reaction conditions are mild. Therefore, the method has broad development prospects.
Intramolecular annulation of aromatic rings with N-sulfonyl 1,2,3-triazoles: Divergent synthesis of 3-methylene-2,3-dihydrobenzofurans and 3-methylene-2,3-dihydroindoles
Tang, Xiang-Ying,Zhang, Yong-Sheng,He, Lv,Wei, Yin,Shi, Min
supporting information, p. 133 - 136 (2015/01/09)
The controllable synthesis of 3-methylene-2,3-dihydrobenzofurans 2 and 3-methylene-2,3-dihydroindoles 5 has been developed through Rh-catalyzed intramolecular annulation of aromatic rings with azavinyl carbenes. This journal is
Formal total synthesis of 2-pupukeanone via radical mediated cyclisation of an enyne
Srikrishna,Vijaykumar,Sharma
, p. 766 - 770 (2007/10/03)
Diels-Alder reaction of the dienone 12, obtained by C-alkylation of sodium 2,6-dimethylphenoxide, with acrylonitrile and phenyl vinyl sulfones generate the enynes 14 and 17. Tributyltin radical addition to the terminal acetylene in 14 and 17 lead to the v
