21080-66-0Relevant academic research and scientific papers
Syntheses of sulfated glycopolymers and analyses of their BACE-1 inhibitory activity
Nishimura, Yuri,Shudo, Hiroki,Seto, Hirokazu,Hoshino, Yu,Miura, Yoshiko
, p. 6390 - 6395 (2013)
The glycopolymers for glycosaminoglycan mimic were synthesized, and the inhibitory effects of Alzheimer's β-secretase (BACE-1) were examined. The regio-selective sulfation was conducted on N-acetyl glucosamine (GlcNAc), and the acrylamide derivatives were
Interaction analyses of amyloid β peptide (1-40) with glycosaminoglycan model polymers
Miura, Yoshiko,Mizuno, Hikaru
supporting information; experimental part, p. 1004 - 1009 (2010/12/19)
We synthesized a novel glycopolymer library with 6-sulfo-GlcNAc and glucuronicacid(GlcA) based on the structure of glycosaminoglycans. The molecular weights of the polymers were controlled via living radical polymerization. The interactions of Aβ(1-40)ith glycopolymers were analyzed by inhibition activity of protein aggregation using ThT fluorescence assay, atomic force microscopy observation, and CD spectra. The inhibition activity of Aβ was much affected by the sugar structure and molecular weight of the polymer. The glycopolymers carrying 6-sulfo-GlcNAc showed inhibition activity toward Aβ aggregate, and those with 6-suflo-GlcNAc and GlcA showed the strong inhibition activity. The glycopolymer libraries yielded valuable information about Aβ aggregate with glycosaminoglycans.
