21080-80-8

Basic information

• Product Name: ethyl 4-cyclopropyl-2,4-dioxobutanoate
• Synonyms: ethyl 4-cyclopropyl-2,4-dioxobutanoate;4-cyclopropyl-2,4-diketo-butyric acid ethyl ester;4-cyclopropyl-2,4-dioxobutanoic acid ethyl ester;MFCD09052462;a,g-Dioxo-cyclopropanebutanoic acid ethyl ester;4-cyclopropyl-2,4-dioxo-butyric acid ethyl ester;Cyclopropanebutanoic acid, α,γ-dioxo-, ethyl ester
• CAS NO: 21080-80-8
• Molecular Formula: C₉H₁₂O₄
• Molecular Weight: 184.18918
• Mol File: 21080-80-8.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 149 °C(Press: 23 Torr)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.79±0.20(Predicted)
• CAS DataBase Reference: ethyl 4-cyclopropyl-2,4-dioxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-cyclopropyl-2,4-dioxobutanoate(21080-80-8)
• EPA Substance Registry System: ethyl 4-cyclopropyl-2,4-dioxobutanoate(21080-80-8)

Safety Data

• Hazardous Substances Data: 21080-80-8(Hazardous Substances Data)

Usage

General Description

Ethyl 4-cyclopropyl-2,4-dioxobutanoate is a chemical compound with the molecular formula C9H12O4. It is a ester, which is a type of organic compound formed by the reaction of an alcohol with a carboxylic acid. This particular ester is derived from cyclopropyl and 2,4-dioxobutanoic acid. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various drug molecules. It is also used as a flavoring agent in the food industry. However, it is important to handle ethyl 4-cyclopropyl-2,4-dioxobutanoate with care, as it can be hazardous if not properly handled and stored.

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 133261-06-0 ethyl 3-cyclopropyl-1H-pyrazole-5-carboxylate 
• 1402585-07-2 C₁₃H₁₂ClN₃O*ClH 
• 1354822-41-5 ethyl 6-cyclopropyl-1-{[4-(methyloxy)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-4-carboxylate 
• 957500-07-1 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylic acid 
• 136283-92-6 C₈H₉ClN₂O 

Relevant articles and documents

Substituted Cyclohexylamine Compounds

The present disclosure provides substituted cyclohexylamine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Design, synthesis and biological evaluation of 1H-pyrazole-5-carboxamide derivatives as potential fungicidal and insecticidal agents

A series of novel 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety were designed and synthesized by a facile method, and their structures were characterized by 1H NMR, mass spectrometry and elemental analysis. Bioassay results showed that most of the title compounds showed potent fungicidal activities against Erysiphe graminis and insecticidal activity against Aphis fabae. Especially, compound 9b has EC50 values of 3.04 mg/L against Erysiphe graminis, of which the fungicidal activity is better than that of the commercial fungicide Thifluzamide and Azoxystrobinare; compound 9l has LC50 values of 3.81 mg/L against Aphis fabae, which was comparable with the commercial insecticide Tolfenpyrad. It is suggested that 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety could be considered as a precursor structure for further design of pesticides. Graphical Abstract: A series of novel 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety were designed and synthesized by a facile method, and their structures were characterized by 1H NMR, mass spectrometry and elemental analysis. Bioassay results showed that most of the title compounds showed potent fungicidal activities against Erysiphe graminis and insecticidal activity against Aphis fabae. Especially, compound 9b has EC50 values of 3.04 mg/L against Erysiphe graminis, of which the fungicidal activity is better than that of the commercial fungicide Thifluzamide and Azoxystrobinare; compound 9l has LC50 values of 3.81 mg/L against Aphis fabae, which was comparable with the commercial insecticide Tolfenpyrad. It is suggested that 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety could be considered as a precursor structure for further design of pesticides.[Figure not available: see fulltext.]

SUBSTITUTED PYRROLIDINE COMPOUNDS

The present disclosure provides substituted pyrrolidine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.