210829-70-2

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 120-57-0 piperonal 
• 88977-32-6 2-cyanoethyl 3-amino-2-butenoate 

Downstream Products

• 210829-71-3 4-Benzo[1,3]dioxol-5-yl-5-[3-(4,4-diphenyl-piperidin-1-yl)-propylcarbamoyl]-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester 
• 210829-72-4 4-Benzo[1,3]dioxol-5-yl-5-[3-(4,4-diphenyl-piperidin-1-yl)-propylcarbamoyl]-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Identification of a dihydropyridine as a potent α(1a) adrenoceptor- selective antagonist that inhibits phenylephrine-induced contraction of the human prostate

A number of novel dihydropyridine derivatives based upon 1,4-dihydro-3- (methoxycarbonyl)-2,6-dimethyl-4-(4-nitrophenyl)-5-((3-(4,4- dihyphenylpiperidin-1-yl)propyl)aminocarbonyl)pyridine (4) have been synthesized and tested at cloned human α adrenoceptors as well as the rat L- type calcium channel. Within this compound series, 5-(aminocarbonyl)-1,4- dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-((3-(4,4-diphenylpiperidin-1- yl)propyl)aminocarbonyl)pyridine (19)displayed good binding affinity and selectivity for the α(1a) adrenoceptor (pK(i) = 8.73) and potently inhibited (pA2 = 9.23) phenylephrine-induced contraction of the human prostate.