210833-18-4Relevant academic research and scientific papers
Aromatization via a dibromination-double dehydrobromination sequence: A facile and convenient synthetic route to 2,6-bis(trifluoroacetyl)phenols
Sevenard, Dmitri V.,Kazakova, Olesya,Schoth, Ralf-Matthias,Lork, Enno,Chizhov, Dmitri L.,Poveleit, Joern,Roeschenthaler, Gerd-Volker
experimental part, p. 1867 - 1878 (2009/04/07)
An efficient and reliable method to synthesize 2,6-bis(trifluoroacetyl) phenols bearing various substituents in the 4-po-sition was developed. These valuable fluorinated building blocks were obtained from the corresponding cyclohexanones in a facile and convenient procedure, demonstrated to be superior to the traditional approaches. The application of this methodology to cyclohex-ane-1,4-dione opened access to 2,5-bis(polyfluoroacyl)-1,4- hydroquinones. Structural peculiarities of the obtained phenols as well as their 1,3-dicarbonyl or 1,3,5-tricarbonyl precursors are discussed on the basis of multinuclear NMR spectroscopy.
