210836-90-1Relevant academic research and scientific papers
Kras inhibitory cyclic peptide compound
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Paragraph 0362; 0458-0459, (2021/06/03)
The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.
Design, syntheses, and evaluation of Taspase1 inhibitors
Lee, Jeong Tae,Chen, David Y.,Yang, Zhimou,Ramos, Alexander D.,Hsieh, James J.-D.,Bogyo, Matthew
supporting information; experimental part, p. 5086 - 5090 (2010/03/31)
Taspase1 is a threonine protease responsible for cleaving MLL (Mixed-Lineage Leukemia) to achieve proper HOX gene expression. Subsequent studies identified additional Taspase1 substrates including Transcription Factor IIA (TFIIA) and Drosophila HCF. Taspa
Concise synthesis of ω-borono-α-amino acids
Reddy, Venkata Jaganmohan,Chandra, J. Subash,Reddy, M. Venkat Ram
, p. 889 - 891 (2007/10/03)
A short protocol for the practical scale synthesis of several ω-borono-α-amino acids is described via the alkylation of benzophenone glycinimines with various electrophiles. This journal is The Royal Society of Chemistry.
