21084-85-5

Upstream product

• 75430-99-8 5-(p-chlorophenyl)-3-(trimethylsiloxy)-1,2,4-oxadiazole 
• 4461-36-3 4-chlorobenzoyl isocyanate 
• 5816-82-0 (4-chloro-benzoyl)-carbamoyl azide 

Downstream Products

• 21084-91-3 3-methoxy-5-(4-chlorophenyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Reactions of Trimethylsilyl Azide with Heterocumulenes

Trimethylsilyl azide (TMSA) reacted with aryl isocyanates to give arylcarbamoyl azides, 1-aryl-5(4H)-tetrazolinones, and / or 1-aryl-4-(arylcarbamoyl)-5(4H)-tetrazolinones, whose yields were dependent on the reaction conditions.The reaction between TMSA and benzoyl or thiobenzoyl isocyanates provides a facile method for the preparation of 5-aryl-3-hydroxy-1,2,4-oxadiazoles or -1,2,4-thiadiazoles, respectively.However, with phenyl or benzoyl isothiocyanate, 1-anilino-1,2,3,4-thiatriazole or benzoylcyanamide was obtained in low yield, respectively.TMSA reacted with carbodiimides to afford the corresponding 5-aminotetrazoles.Tetraphenylsuccinimide, N-(diphenylacetyl)tetraphenylsuccinimide, 1,3-bis(diphenylmethyl)urea, and / or benziloylamide were obtained from the reaction of TMSA with diphenyl ketene.The pathways for the formation of the above products are also described.