210890-14-5

Upstream product

• 210761-80-1 methyl (2E,4R,5R)-4,5-dimethyl-7-oxo-2-heptenoate 
• 100-46-9 benzylamine 
• 210890-19-0 (E)-(4R,5R)-7-Benzylamino-7-cyano-4,5-dimethyl-hept-2-enoic acid methyl ester 

Relevant academic research and scientific papers

Novel and stereocontrolled synthesis of enantiopure and polyalkyl substituted piperidines

A flexible and stereodivergent synthesis of enantiopure piperidines with up to four alkyl-substituted chiral centers is reported which proceeds by way of a double nucleophilic addition of primary amines to the 7-oxo-2-enimides 1. These in turn are accessible via the silyloxy-Cope rearrangement of chiral syn-aldol products.