210963-75-0

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 
• 210962-75-7 3-hydroxy-4-iodobenzonitrile 
• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 71999-74-1 tert-butyl N-(2-chloroethyl)carbamate 

Downstream Products

• 538335-85-2 methyl 2-acetamido-3-[2-(2-tert-butoxycarbonylaminoethoxy)-4-cyanophenyl]acrylate 
• 538335-90-9 methyl 2-acetamido-3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate 
• 538336-04-8 ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate 
• 252261-63-5 ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate 
• 538336-01-5 ethyl 3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate 
• 538335-93-2 methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate 
• 1026523-08-9 ethyl 3-[2-[2-[4-(4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate 

Relevant academic research and scientific papers

AMIDINOPHENYLPYRUVIC ACID DERIVATIVES

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.

Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids

An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiety to

BENZAMIDINE DERIVATIVES

A benzamidine derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an effect of inhibiting the blood coagulation based on their excellent effect of inhibiting activated blood-coagulation factor X. Thus, a blood-coagulation inhibitor or an agent for preventing or treating thrombosis or embolism, containing one of those compounds as the active ingredient, is provided.

Benzamidine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.