210964-04-8

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[[4-(methoxycarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 210964-04-8
• Molecular Formula: C19H27NO4
• Molecular Weight: 333.428
• Mol File: 210964-04-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[[4-(methoxycarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[[4-(methoxycarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester(210964-04-8)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[[4-(methoxycarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester(210964-04-8)

Safety Data

• Hazardous Substances Data: 210964-04-8(Hazardous Substances Data)

Usage

Tertiary ester derivative

The chemical is a derivative of piperidinecarboxylic acid, which is a five-membered heterocyclic ring, and is a tertiary ester.

Molecular weight

The molecular weight of the chemical is 351.47 g/mol.

Physical appearance

The chemical is a white to off-white solid.

Melting point

The melting point of the chemical is around 60-65°C.

Stability

The chemical is stable under normal temperatures and pressures.

Storage

It should be stored in a cool, dry, and well-ventilated area.

Uses

The chemical is commonly used in organic synthesis and pharmaceutical research.

Potential applications

The compound has various potential applications in the fields of chemistry and medicine.

Upstream product

• 14295-52-4 4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester 
• 209808-15-1 4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 147969-86-6 4-{[1-(tert-Butoxycarbonyl)-4-piperidinyl]methyl}benzoic acid 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity

We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety