210992-23-7

Usage

Chemical class

Piperazine derivatives

Structure

Heterocyclic compound with a piperazine ring and a phenyl group

Phenyl group features

Contains both chlorine and fluorine atoms

Potential biological activity

Studied for pharmacological properties

Possible applications

Antipsychotic or antidepressant use

Field of interest

Medicinal chemistry for new drug development

Research status

Further research needed to understand potential uses and effects

Upstream product

• 110-85-0 piperazine 
• 33863-76-2 1-bromo-3-chloro-5-fluorobenzene 

Downstream Products

• 1027979-75-4 3-[4-(3-chloro-5-fluoro-phenyl)-piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one 

Relevant academic research and scientific papers

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes

A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)- 4-pyrazolyl]-1-trans-propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor acti

Pyrazole derivatives

The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.