211053-97-3Relevant articles and documents
PhFl acetic acid: A new linker for solid phase organic synthesis
Bleicher, Konrad H.,Wareing, James R.
, p. 4591 - 4594 (2007/10/03)
A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described. Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified. TFA treatment releases the corresponding products in high purity.