211103-69-4

Upstream product

• 94838-59-2 tert-butyl 4-aminophenethylcarbamate 
• 3544-25-0 p-aminophenylacetonitrile 
• 68384-47-4 [4-(methylamino)phenyl]acetonitrile 

Relevant academic research and scientific papers

triAZOLOtriAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS

The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyperfunctioning, such as certain types cancers. Compounds of formula (1) and methods of preparing the compounds are disclosed in the invention.

Amide derivatives and medicinal compositions thereof

PCT No. PCT/JP98/00237 Sec. 371 Date May 7, 1999 Sec. 102(e) Date May 7, 1999 PCT Filed Jan. 22, 1998 PCT Pub. No. WO98/32742 PCT Pub. Date Jul. 30, 1998An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle. (The symbols in the formula have the following meanings. (wherein A: heteroarylene; X: bond, O, S, -NR5-, -NR5CO-, -NR5CONH-, -NR5SO2- or -NR5C(=NH)NH-; R1: -H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl; R2a, R2b: -H or -lower alkyl, which may be the same or different; R3: -H or -lower alkyl; R4a, R4b: -H or -OH, which may be the same different, or R4a and R4b are taken together to form =O or =N DIFFERENCE O-lower alkyl; and R5: -H or -lower alkyl.